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Every Little Thing - Every Best Single COMPLETE 2022



 


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The album is a double album that includes selected songs from the singles released by the duo between 2000 and 2009, including the songs "Piece of Your Heart" and "Never Forget You", which are new recordings. Track listing References Category:2009 compilation albums Category:Every Little Thing (duo) albumsLncRNA FER1L4 promotes epithelial-mesenchymal transition and promotes the proliferation and migration of hepatocellular carcinoma cells by regulating miR-203. Epithelial-mesenchymal transition (EMT) is an important step for cancer metastasis. Long noncoding RNAs (lncRNAs) have been revealed as key regulators during EMT. FER1L4, a lncRNA, has been identified as an oncogene in many types of cancer, but the function of FER1L4 in hepatocellular carcinoma (HCC) remains elusive. In this study, we demonstrated that FER1L4 was upregulated in HCC tissues and cell lines. FER1L4 overexpression promoted the proliferation and migration of HCC cells, while FER1L4 downregulation suppressed cell proliferation and migration in vitro. We further found that FER1L4 upregulation increased the expressions of the mesenchymal markers N-cadherin, vimentin and snail, and decreased the expression of the epithelial marker E-cadherin. Moreover, FER1L4 upregulation promoted EMT, as evidenced by increased expression of the mesenchymal markers and decreased expression of the epithelial marker. In addition, FER1L4 upregulation increased the expression of miR-203, which could be the underlying mechanism of FER1L4-induced EMT. Furthermore, FER1L4 upregulation significantly inhibited miR-203 expression, while FER1L4 downregulation increased the miR-203 expression. miR-203 overexpression abrogated the FER1L4-induced promotion of EMT, cell proliferation and migration. In conclusion, our study identified FER1L4 as a novel oncogene that promoted the EMT and proliferation of HCC cells./** * This file is part of Graylog. * * Graylog is free software: you can redistribute it and/or modify * it under the terms of the GNU General Public License as published

 

 


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Every Little Thing - Every Best Single COMPLETE 2022

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